proteinNIDDM

ANNUAL MEETING

HIGHLIGHTS

Animal-Based Protein in Individuals with NIDDM

Laurie Hackward, Indiana University

Reviewed by Bonnie Brown, RD

Protocol Description:

This study hypothesizes an increased glomerular filtration rate (GFR) may be associated with a diet high in animal protein.

24 male/24 female, well-controlled type II diabetic subjects >35-75 years were studied.

Subjects followed a high animal protein or vegetarian diet for six weeks each in randomized cross-over design.

Diet composition: 54% carbohydrate, 16% protein, 30% fat.

Measures were taken of renal plasma flow (RPF), GFR, lipids.

Patient satisfaction questionnaire, 3-day food diary, indirect calorimetry

Results: The only difference seen between the diets was an increase in HDL-cholesterol in the vegetarian diet. Both diets showed improved glycemic control and HbA1c. No change was seen in RPF in either diet.

Dietary Protein Affects Calcium Metabolism

Presented by Donna Caseria, MS, RD, Yale University

Reviewed by Linda Brinkley, MS, RD

Protocol Description:

16 healthy Asian and Caucasian females, ages 20 - 40 years, normal weights

Diet:

--The Basic Diet was kept constant at 800 mg Calcium, 800 - 1200 mg

Phosphorus, and 100 meq Sodium.

--The variable was dietary protein levels. Protein levels of 0.7 g/kg, 0.8 g/kg, 0.9 g/kg, 1.0 g/kg, and 2.1 g/kg Body Weight were used.

--Fiber content was the same in low protein diets and in the moderate protein diets.

Results: Protein levels of 0.7 g/kg and 0.8 g/kg B.W. resulted in increased PTH and Vitamin D in all subjects. Urinary calcium was also decreased in these subjects. The percent calcium absorption was low on the low protein diet and normal on the high protein diet. At 2.1g protein/kg B.W. subjects had hypercalciuria and PTH was normal to decreased. At 0.9 g/kg and 1.0 g/kg B.W. the PTH and urinary calcium were normal. The usual protein intake for these women was estimated to be 1.0 - 1.5 g/kg B.W. Therefore, the RDA for protein of 0.8 g/kg B.W. may be too low to maintain bone health.